Acetic Acid → 2-Methyl-6-ureidobenzyl alcohol

HRID 1762198Notes

Reaction equation

HRID 1762198 reaction equation
[O-:1][C:2]#[N:3].[K+].[NH2:5][C:6]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[C:7]=1[CH2:8][OH:9].C(O)(=O)C>O>[CH3:14][C:10]1[C:7]([CH2:8][OH:9])=[C:6]([NH:5][C:2]([NH2:3])=[O:1])[CH:13]=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 11378442Potassium cyanateHCID 15339417(2-Amino-6-methylphenyl)methanol

Product 1

HCID 143684562-Methyl-6-ureidobenzyl alcoholYield 73.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of potassium cyanate (1.62 g) in water (5 ml) was dded dropwise to a mixture of 2-amino-6-methylbenzyl alcohol (1.37 g), water (5 ml), and acetic acid (6 ml) at room temperature. After being stirred for 2.5 hours, the resulting precipitates were collected by filtration, washed with water, and dried to give 6-methyl-2-ureidobenzyl alcohol (1.33 g).

Workup

  1. customthe resulting precipitates
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-225e8892761e48c897ea4c61c9fc54d6
Source dataset
uspto-grants-1989_05
Patent number
US04831041

Reaction notes

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