Acetone → HCID 20042512, compound

HRID 1762201Notes

Reaction equation

HRID 1762201 reaction equation
C[I:2].[C:3]([C:5]1[CH:26]=[CH:25][CH:24]=[CH:23][C:6]=1[CH2:7][O:8][C:9]1[C:10]2[N:11]([C:15]([CH2:19][N:20]([CH3:22])[CH3:21])=[C:16]([CH3:18])[N:17]=2)[CH:12]=[CH:13][CH:14]=1)#[N:4].[CH3:27]C(C)=O>ClC(Cl)Cl>[I-:2].[C:3]([C:5]1[CH:26]=[CH:25][CH:24]=[CH:23][C:6]=1[CH2:7][O:8][C:9]1[C:10]2[N:11]([C:15]([CH2:19][N+:20]([CH3:27])([CH3:22])[CH3:21])=[C:16]([CH3:18])[N:17]=2)[CH:12]=[CH:13][CH:14]=1)#[N:4]

Participants

5

Reactant 3

HCID 180AcetoneHCID 6328Methyl iodideHCID 14368493HCID 14368493, compound

Product 1

HCID 20042512HCID 20042512, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Methyl iodide (1.33 g) was added dropwise to a solution of 8-(2-cyanobenzyloxy)-3-dimethylaminomethyl-2-methylimidazo[1,2-a]pyridine (3 g) in the mixture of acetone (30 ml) and trichloromethane (30 ml) at room temperature and the mixture was stirred for 24 hours. The resulting precipitate was collected by filtration, washed with acetone, and dried in a desiccator to give 8-(2-cyanobenzyloxy)-2-methyl-3-trimethylammoniomethylimidazo[1,2-a]pyridine iodide.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with acetone
  3. customdried in a desiccator

Sources & evidence

ORD record
ord-5931d682c91e4d60a644f10bd64ce5d9
Source dataset
uspto-grants-1989_05
Patent number
US04831041

Reaction notes

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