Thiocyanate → HCID 14053646, compound

HRID 1762267Notes

Reaction equation

HRID 1762267 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:18])=[C:6]([N:8]2[C:16]([Cl:17])=[C:15]3[C:10]([CH2:11][CH2:12][CH2:13][CH2:14]3)=[N:9]2)[CH:7]=1.[S-:19][C:20]#[N:21]>>[NH2:21][C:20]1[S:19][C:3]2[CH:4]=[C:5]([F:18])[C:6]([N:8]3[C:16]([Cl:17])=[C:15]4[C:10]([CH2:11][CH2:12][CH2:13][CH2:14]4)=[N:9]3)=[CH:7][C:2]=2[N:1]=1

Participants

3

Reactant 2

HCID 9322ThiocyanateHCID 14053648HCID 14053648, compound

Product 1

HCID 14053646HCID 14053646, compound

Procedure

2-(5-Amino-2-fluorophenyl)-3-chloro-4,5,6,7-tetrahydro-2H-indazole (IX) is reacted with a thiocyanate and then with a halogen to give 2-(2-amino-6-fluorobenzothiazol-5-yl)-3-chloro-4,5,6,7-tetrahydro-2H-indazole (X).

Sources & evidence

ORD record
ord-a8cbccd78e5b4191a0fb0b41ebad3088
Source dataset
uspto-grants-1989_05
Patent number
US04831149

Reaction notes

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