Methanol → Dihydro-3-(2-hydroxyethyl)-2(3H)-furanone
Reaction equation
[C:1](OC)(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH2:9]1[O:11][CH2:10]1.[Na+].[Cl-].C[OH:15]>>[OH:6][CH2:1][CH2:2][CH:3]1[CH2:5][CH2:10][O:11][C:9]1=[O:15]Participants
5
Conditions
- Temperature
- 80 °C
Procedure
A mixture of 58 g of methyl acetoacetate, 44 g of ethylene oxide, 3 g of NaCl and 70 ml of methanol was heated in an autoclave under autogenous pressure for 12 hours at 80° C. Thereafter, the methanol was distilled off, the residue was taken up with water, and the solution was washed with a little chloroform and distilled. 52.6 g of 2-(2-hydroxyethyl)-γ-butyrolactone were obtained, corresponding to a yield of 81% of theory.
Workup
- distillationThereafter, the methanol was distilled off
- washthe solution was washed with a little chloroform
- distillationdistilled
Sources & evidence
- ORD record
- ord-4d2ce2874c7f4713a848ac23a58f3fe2
- Source dataset
- uspto-grants-1989_05
- Patent number
- US04831166
Reaction notes
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