Hydrochloric Acid → HCID 20043143, compound

Participants

Reaction Steps

19 g 3-methylamino-1-benzoxepin-5(2H)-one were suspended in 130 ml methanol, and gaseous hydrogen chloride was introduced into the suspension with stirring in order to convert it into its hydrochloride. The amine thereby goes into solution with warming. Subsequently approximately 40 ml methanol were distilled from the solution. The solution was allowed to stand to crystallize the hydrochloride which was formed, and the crystals which formed were removed by filtration. 22 g 3-methylamino-1-benzoxepin-5(2H)-one hydrochloride were obtained which were used without further purification in the following hydrogenation.

Provenance & Evidence