Hydrochloric Acid → HCID 53855211, compound

Participants

Reaction Steps

A mixture of 6 parts methyl 1-[(dicyclohexyl)methyl]-1H-imidazol-5-carboxylate, 6 parts of a sodium hydroxide solution 50% and 100 parts of water is stirred for 2 hours at reflux temperature. The reaction mixture is acidified with concentrated hydrochloric acid and the product is extracted with trichloromethane. The extract is dried, filtered and evaporated. The residue is boiled for 2 hours in acetonitrile. The precipitated product is filtered off and dried, yielding 1-[(dicyclohexyl)methyl]-1H-imidazole-5-carboxylic acid; mp. 253° C. (compound 4).

Provenance & Evidence