Ammonia → HCID 14254897, compound

HRID 1762420Notes

Reaction equation

HRID 1762420 reaction equation
C[O:2][C:3]([CH:5]1[N:9]([CH2:10][C:11]#[C:12][CH2:13][N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[C:8](=[O:19])[CH2:7][CH2:6]1)=O.[NH3:20]>CO>[O:19]=[C:8]1[N:9]([CH2:10][C:11]#[C:12][CH2:13][N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:5]([C:3]([NH2:20])=[O:2])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14254896HCID 14254896, compound

Product 1

HCID 14254897HCID 14254897, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An ice water chilled solution of 5-methoxycarbonyl-1-[4-(1-pyrrolidinyl)-2-butynyl]-2-pyrrolidinone (5.52 g) in sieve dried methanol (175 ml) was treated with anhydrous ammonia for fifteen minutes and was allowed to stand at ambient temperature overnight. The solution was concentrated to a brown solid (3.33 g). The solid was recrystallized from toluene (100 ml) to give 2.03 g of slightly brown crystals, mp 146°-147.5° C.

Workup

  1. concentrationThe solution was concentrated to a brown solid (3.33 g)
  2. customThe solid was recrystallized from toluene (100 ml)
  3. customto give 2.03 g of slightly brown crystals, mp 146°-147.5° C.

Sources & evidence

ORD record
ord-7ed534ff2f4744c9a4c9a75c8db8794b
Source dataset
uspto-grants-1989_05
Patent number
US04833139

Reaction notes

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