Ammonia → HCID 14254899, compound

HRID 1762421Notes

Reaction equation

HRID 1762421 reaction equation
C[O:2][C:3]([CH:5]1[N:9]([CH2:10][C:11]#[C:12][CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:8](=[O:20])[CH2:7][CH2:6]1)=O.[NH3:21]>CO>[O:20]=[C:8]1[N:9]([CH2:10][C:11]#[C:12][CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:5]([C:3]([NH2:21])=[O:2])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14254898HCID 14254898, compound

Product 1

HCID 14254899HCID 14254899, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An ice water chilled solution of 5-methoxycarbonyl-1-[4-(1-piperidinyl)-2-butynyl]-2-pyrrolidinone (5.44 g) in sieve dried methanol (175 ml) was treated with anhydrous ammonia for fifteen minutes and was allowed to stand at ambient temperature overnight. The solution was concentrated to a brown solid (5.00 g). The solid was recrystallized from toluene (125 mL) to give 3.85 g of slightly brown crystals, mp 143°-145° C.

Workup

  1. concentrationThe solution was concentrated to a brown solid (5.00 g)
  2. customThe solid was recrystallized from toluene (125 mL)
  3. customto give 3.85 g of slightly brown crystals, mp 143°-145° C.

Sources & evidence

ORD record
ord-d116cfdce6a64870a0d9acedcd2ccaeb
Source dataset
uspto-grants-1989_05
Patent number
US04833139

Reaction notes

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