HCID 178471600, compound → HCID 20040885, compound

HRID 1762438Notes

Reaction equation

HRID 1762438 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([NH:13]/[C:14](/[CH3:21])=[CH:15]\[C:16]([O:18]CC)=O)=[CH:11][NH:10][N:9]=2)=[CH:4][CH:3]=1>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[O:18]=[C:16]1[CH:15]=[C:14]([CH3:21])[NH:13][C:12]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)=[N:9][NH:10][C:11]1=2

Participants

3

Reactant 1

HCID 178471600HCID 178471600, compound

Product 1

HCID 20040885HCID 20040885, compoundYield 76.5%

Reagents, catalysts & solvents 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Solvent

Procedure

Ethyl 3-[3-(4-chlorophenyl)-pyrazol-4-ylamino]crotonate (D14) (0.6 g) was added to refluxing Dowtherm A (20 ml) under nitrogen and heated for 20 min. The cooled solution was diluted with petroleum ether (40°-60°; 100 ml) and the resulting solid was collected and washed well with petroleum ether to afford the title compound (0.39 g) m.p. 324°-327° C. (Found: C, 60.06; H, 3.74; N, 16.14% C13H10N3OCl requires C, 60.13; H, 3.88; N, 16.18%)

Workup

  1. temperatureheated for 20 min
  2. customthe resulting solid was collected
  3. washwashed well with petroleum ether

Sources & evidence

ORD record
ord-043849b772c64bfaa683bdda1c731f86
Source dataset
uspto-grants-1989_05
Patent number
US04833136

Reaction notes

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