Phosphorus oxychloride → HCID 178426079, compound

Participants

Reaction Steps

A mixture of 4,7-dihydro-7-oxo-5-methyl-3-(4-chlorophenyl)-1H-pyrazolo[4,3-b]pyridine (D15) (0.8 g) in phosphoryl chloride (20 ml) was heated under reflux under nitrogen for 20 mins and then evaporated to dryness in vacuo. The residue was basified with 10% sodium carbonate solution and extracted with ethyl acetate (3×200 ml). The organic fraction was washed with water, dried (Na2SO4), and evaporated to dryness in vacuo, and recrystallised from ethyl acetate to afford the title compound (0.4 g), m.p. 243°-245° C.

Provenance & Evidence