1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → HCID 20040895, compound

HRID 1762444Notes

Reaction equation

HRID 1762444 reaction equation
[CH3:1][C:2]1[N:3]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:4]=[CH:5][C:6]=1[NH:7]/[C:8](/[CH3:15])=[CH:9]\[C:10]([O:12]CC)=O.C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>>[O:12]=[C:10]1[CH:9]=[C:8]([CH3:15])[NH:7][C:6]2=[C:2]([CH3:1])[N:3]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:4]=[C:5]12

Participants

3

Reactant 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)2×HCID 70394620HCID 70394620, compound

Product 1

HCID 20040895HCID 20040895, compound

Procedure

Ethyl 3-(3-methyl-2-phenylpyrazol-4-ylamino)crotonate (0.200 g) was added to boiling Dowtherm A (5 ml) under nitrogen. The mixture was heated under reflux for 30 mins and then allowed to cool. Petroleum ether (60°-80° C.) was added to the cooled Dowtherm solution and the required pyrazolopyridone precipitated out. The title compound (0.120 g) was filtered off and washed thoroughly with hot petroleum ether.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 30 mins
  3. temperatureto cool
  4. customthe required pyrazolopyridone precipitated out
  5. filtrationThe title compound (0.120 g) was filtered off
  6. washwashed thoroughly with hot petroleum ether

Sources & evidence

ORD record
ord-7c2c66c5cbb347e5a9dff2ed2a2470cb
Source dataset
uspto-grants-1989_05
Patent number
US04833136

Reaction notes

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