HCID 20040847, compound → HCID 20040849, compound

Participants

Reaction Steps

A solution of sodium metaperiodate (0.1 g.) in water (2 ml.) was added to a stirred solution of (1RS,2RS)-1-{4-[4-(2-hexylthioethyl)pyrazol-1-yl]butyl}-1,2,3,4-tetrahydro-2-p-hydroxyphenyl-2-methylnaphth-6-ol (Example 1; 0.23 g.) in a mixture of methanol (4 ml.) and tetrahydrofuran (4 ml.) and the mixture was stirred at laboratory temperature for 16 hours, diluted with water (20 ml.) and extracted three times with methylene chloride (10 ml. each time). The combined extracts were dried and evaporated to dryness and the residue was purified by chromatography on a silica gel column using a 49:1 v/v mixture of ethyl acetate and ethanol as eluent. There was thus obtained as an oil (1RS,2RS)-1-{4-[4-(2-hexylsulphinylethyl)pyrazol-1-yl]butyl}-1,2,3,4-tetrahydro-2-p-hydroxyphenyl-2-methylnaphth-6-ol.

Provenance & Evidence