Ethanol → HCID 178511970, compound

Participants

Reaction Steps

The product of Stage (i) (0.8 g) was stirred in ethanol (50 ml) under a hydrogen atmosphere and over 10% palladium on carbon catalyst (0.8, 50% aqueous paste). After 3 h, the catalyst was filtered off [hydrogen uptake=250 ml] and the filtrate evaporated to dryness, to give an oil which was evaporated to a foam (0.5 g), m.p. 80°-92°. A portion of the foam (0.3 g) in hot ethyl acetate was added to an equivalent amount of maleic acid in hot ethyl acetate. The mixture was cooled and the solid collected, washed with ethyl acetate and dried in vacuo at 60° for 2 days to give the title compound, m.p. >110° (decomposes).

Provenance & Evidence