Ammonia → HCID 86743054, compound

HRID 1762487Notes

Reaction equation

HRID 1762487 reaction equation
[ClH:1].[C:2]1([CH2:8][O:9][C:10]([NH:12][CH2:13][CH2:14][C:15]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([C:24](=[NH:28])OCC)[CH:22]=3)[NH:17][CH:16]=2)=[O:11])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:29]>>[OH2:9].[ClH:1].[NH2:29][N:28]=[CH:24][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][CH:20]=1)[NH:17][CH:16]=[C:15]2[CH2:14][CH2:13][NH:12][C:10](=[O:11])[O:9][CH2:8][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20041395HCID 20041395, compound

Product 1

HCID 86743054HCID 86743054, compound

Procedure

A solution of the product of Stage (i) (0.1 g) in methanolic ammonia solution (25 ml) was stirred at room temperature for 72 h. The mixture was reduced to dryness and the residual oil triturated with a mixture of ethyl acetate and ethanol to give the title compound as a powder (0.06 g), m.p. 248°-250°.

Workup

  1. customthe residual oil triturated with a mixture of ethyl acetate and ethanol

Sources & evidence

ORD record
ord-ecfba88c16ab46f99d23743a4de4432f
Source dataset
uspto-grants-1989_05
Patent number
US04833153

Reaction notes

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