2-Chloro-N,N-dimethylethylamine → HCID 54328146, compound

Participants

Reaction Steps

500 mg of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-pyrrolidone was dissolved in 5 ml of dimethylformamide and 0.2 g of sodium hydride and 0.2 g of 2-dimethylaminoethyl chloride were successively added thereto under ice-cooling. Then the obtained mixture was allowed to react for one hour at room temperature. The reaction mixture was extracted with ethyl acetate, washed with water followed by a saturated saline solution and dried over anhydrous magnesium sulfate. After distilling the ethyl acetate off, the residue was purified by column chromatography with the use of silica gel and benzene/acetone and recrystallized from ethyl acetate/hexane to give 300 mg of the title compound.

Provenance & Evidence