N,S-Diacetyl-DL-cysteinyl-L-proline tert-butyl ester → N-acetyl-3-mercaptovalyl-L-proline

HRID 1762518Notes

Reaction equation

HRID 1762518 reaction equation
C([O:5][C:6](=[O:26])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:25])[C@H:13]([C:18]([S:21]C(=O)C)([CH3:20])[CH3:19])[NH:14][C:15](=[O:17])[CH3:16])(C)(C)C.C(OC(=O)[C@@H]1CCCN1C(=O)C(CSC(=O)C)NC(=O)C)(C)(C)C>>[C:15]([NH:14][C@H:13]([C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:6]([OH:26])=[O:5])=[O:25])[C:18]([SH:21])([CH3:20])[CH3:19])(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 14181603N,S-Diacetyl-DL-cysteinyl-L-proline tert-butyl esterHCID 54234986N-acetyl-3-acetylthiovalyl-L-proline t-butyl ester

Product 1

HCID 53700612N-acetyl-3-mercaptovalyl-L-proline

Procedure

By substituting the product of Example 56 for the N,S-diacetyl-D,L-cysteinyl-L-proline t-butyl ester in the procedure of Examples 54 and 55, the named product is obtained.

Workup

  1. customthe named product is obtained

Sources & evidence

ORD record
ord-cb81b4a61c3648b0b0fb7c82b66627bf
Source dataset
uspto-grants-1989_05
Patent number
US04833152

Reaction notes

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