HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromide ion → 7-(5-Hydroxy-5-methylhexyl)-1,3-dimethylxanthine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromide ion | HCID 259 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Lomifylline | HCID 65599 | — |
| Reactant | 7-(5-Hydroxy-5-methylhexyl)-3-methylxanthine | HCID 13747680 | — |
| Reactant | 1,3-Dimethyl-7-(5-methyl-4-hexenyl)-xanthine | HCID 20041125 | — |
| Reactant | HCID 178418332 | HCID 178418332 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 7-(5-Hydroxy-5-methylhexyl)-1,3-dimethylxanthine | HCID 13747683 | — |
Reaction Steps
Alternatively, it was possible to prepare the compound, inter alia, from 7-(5-hydroxy-5-methylhexyl)-3-methylxanthine (Example 1b) and iodomethane analogously to Example 3, from 1,3-dimethyl-7-(5-oxohexyl)-xanthine and methylmagnesium chloride or bromide in anhydrous ether analogously to Example 9, and from 1,3-dimethyl-7-(5-methyl-4-hexenyl)-xanthine by acid-catalyzed hydration analogously to Example 14.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04833146 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-590b90e31e1c4538baeea3ad2f472939 |
| Source note | uspto-grants-1989_05 |