HCID 20041121, compound → Torbafylline

HRID 1762539Notes

Reaction equation

HRID 1762539 reaction equation
[CH2:1]([O:3][CH2:4][N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[O:21])[CH3:20])[C:10](=[O:22])[N:9]([CH3:23])[C:8]=2[N:7]=[CH:6]1)[CH3:2].[CH3:24][Mg]Cl>CCOCC>[CH2:1]([O:3][CH2:4][N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])([CH3:24])[CH3:20])[C:10](=[O:22])[N:9]([CH3:23])[C:8]=2[N:7]=[CH:6]1)[CH3:2]

Participants

4

Reactant 2

HCID 20041121HCID 20041121, compoundHCID 178418332HCID 178418332, compound

Product 1

HCID 65888Torbafylline

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The compound was also obtained, for example, by Grignard synthesis from 7-ethoxymethyl-3-methyl-1-(5-oxohexyl)xanthine with methylmagnesium chloride in anhydrous ether analogously to Example 9.

Sources & evidence

ORD record
ord-90f2acb407b54655b4331a684a649e0f
Source dataset
uspto-grants-1989_05
Patent number
US04833146

Reaction notes

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