Diethyl Ether → HCID 13747690、化合物

関与物質

反応手順

20.0 g (0.15 mol) of ethylmagnesium bromide are taken as a 40% strength solution in ether, and 27.8 g (0.1 mol) of 3,7-dimethyl-1-(5-oxohexyl)-xanthine in 1 liter of dry ether are metered in dropwise at room temperature, while stirring, whereupon a voluminous precipitate forms. The mixture is heated and is subsequently stirred, while boiling gently under reflux, for one hour. It is then worked up as described in the preceding Example 9 to give 25 g of oily crude product (81.1% of theory), which gradually crystallizes completely and is purified by recrystallization from diisopropyl ether, with the addition of a little ethyl acetate, at the boiling point.

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