Xanthine → HCID 13747693, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5.6 g (0.1 mol) of potassium hydroxide in 100 ml of methanol is added to a suspension of 20.8 g (0.1 mol) of 3-methyl-7-propylxanthine in 250 ml of methanol. On heating, a clear solution forms, and this is evaporated to dryness under reduced pressure. The potassium salt of the xanthine compound which remains is intensively dried under a high vacuum, 500 ml of dimethylformamide and 15.0 g (0.11 mol) of the tertiary alcohol from stage (a) are added and the mixture is stirred at 80° C. for 18 hours. The mixture is worked up analogously to Example 5b, whereupon 25.1 g of crude product (81.4% of theory) are obtained and can be purified by recrystallization from diisopropyl ether, with the addition of a little ethyl acetate, at the boiling point.

Provenance & Evidence