Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloro-1,2-propanediol | HCID 7290 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Methylxanthine | HCID 70639 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | AC1MUDJS | HCID 3616685 | — |
Reaction Steps
83 g (0.5 mol) of 3-methylxanthine are dissolved in 1250 ml of dimethylformamide, and 12 g (0.5 mol) of sodium hydride are added in portions at room temperature, while stirring. Stirring is continued for 30 minutes, after which 55.3 g (0.5 mol) of 1-chloro-2,3-propanediol in 100 ml of dimethylformamide are added dropwise and the mixture is heated for 18 hours at 110° C., while stirring. Working up is carried out as described in Example 55a).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04833146 |
|---|
| Source dataset | uspto-grants-1989_05 |
|---|
| ORD ID | ord-48de970be0dd4fdd8fe52f272b4c9ad9 |
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| Source note | uspto-grants-1989_05 |
|---|
