Cesium carbonate → HCID 54509014, compound

Participants

Reaction Steps

5.5 g (34 mmol) of 5-methoxybenzocyclobutene-1-carboxaldehyde and 13.8 g (42 mmol) of caesium carbonate are introduced under argon into 55 ml of dioxan. While stirring, 8.7 g (39 mmol) of phosphonoacetic acid triethyl ester are added and the whole is then heated at 80° for 2 hours. The reaction mixture is then concentrated, taken up in dichloromethane and washed with water. The organic phase is dried over sodium sulphate and concentrated by evaporation. The crude product so obtained is purified by chromatography on silica gel. 3-(5-methoxybenzocyclobuten-1-yl)acrylic acid ethyl ester is obtained; Rf=0.5, hexane/diethyl ether (4:1).

Provenance & Evidence