p-Toluenesulfonic acid → 2,2-Dimethyl-3-(3-cyclobutoxy-3-oxo-1-propenyl)-cyclopropane-carboxylic acid

HRID 1762611노트

반응식

HRID 1762611 반응식
[CH3:1][C:2]1([CH3:16])[CH:4]([CH:5]=[CH:6][C:7]([O:9][CH2:10][CH2:11][CH3:12])=[O:8])[CH:3]1[C:13]([OH:15])=[O:14].[C:17]1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH3:16][C:2]1([CH3:1])[CH:4]([CH:5]=[CH:6][C:7]([O:9][CH:10]2[CH2:17][CH2:12][CH2:11]2)=[O:8])[CH:3]1[C:13]([OH:15])=[O:14]

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 545705842,2-Dimethyl-3-(3-propoxy-3-oxo-1-propenyl)-cyclopropane-carboxylic acid

생성물 1

HCID 539623272,2-Dimethyl-3-(3-cyclobutoxy-3-oxo-1-propenyl)-cyclopropane-carboxylic acid

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 2.3 g of the product of Step A, 25 ml of toluene and 250 mg of p-toluene sulfonic acid was refluxed for 15 minutes and was cooled. The mixture was stirred for 2 hours at 0° to 5° C. and was filtered. The filtrate was evaporated to dryness under reduced pressure to obtain 1.8 g of (1R, cis, ΔZ) 2,2-dimethyl-3-(3-cyclobutoxy-3-oxo-1-propenyl)-cyclopropane-carboxylic acid.

후처리

  1. temperaturewas refluxed for 15 minutes
  2. temperaturewas cooled
  3. filtrationwas filtered
  4. customThe filtrate was evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-e071e27c89a04875a8c23ad2c0a009c7
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04833163

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