Dicyclohexylcarbodiimide → HCID 20041584, compound

Participants

Reaction Steps

A solution of 21.6 g of the product of Step A in 75 ml of methylene chloride was added with stirring under an inert atmosphere to a solution of 19.9 g of (R, S) cyano-2-(6-phenoxypyridyl)-methanol in 75 ml of methylene chloride and then 1 g of 4-dimethylamino-pyridine was dissolved therein at 0° C. 21 g of dicyclohexylcarbodiimide were added to the mixture which was then stirred at room temperature for 4 hours and was then filtered. The filtrate was evaporated to dryness under reduced pressure at 40° C. and the residue was chromatographed over silica gel. Elution with a 7-3 cyclohexane-ethyl acetate mixture yielded 35.4 g of (R, S) cyano-2-(6-phenoxy-pyridyl)-methyl (1R, cis) 2,2-dimethyl-3-(3-methoxy-3-oxo-propynyl)-cyclopropane-carboxylate.

Provenance & Evidence