Hydrochloric Acid → HCID 54065715, compound

Participants

Reaction Conditions

Reaction Steps

To a solution prepared by dissolving 7.8 g of sodium hydroxide in 20 ml of water was added 17.9 g of Intermediate A, and the resulting mixture was heated with stirring for 5 hours at a reaction mixture temperature of 70° C. After cooling the reaction mixture to room temperature, 16 ml of concentrated hydrochloric acid was added thereto, and the concentration treatment was continued under reduced pressure until a white crystalline precipitate started to separate from the reaction mixture, and then the concentrated solution was cooled with ice-cold water to precipitate the white crystals. These crystals were filtered off, washed with acetone, and dried. Thus, 14.2 g (yield: 87%) of Intermediate B was obtained. Melting Point: 223°-226° C.

Provenance & Evidence