Ethanolamine → HCID 54522853, compound

HRID 1762691Notes

Reaction equation

HRID 1762691 reaction equation
C(O[C:4]([C:6]1[NH:7][N:8]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[S:19]([OH:22])(=[O:21])=[O:20])[C:9](=[O:11])[CH:10]=1)=[O:5])C.[CH2:23]([CH2:25][NH2:26])[OH:24]>C(O)C>[OH:24][CH2:23][CH2:25][NH:26][C:4]([C:6]1[NH:7][N:8]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[S:19]([OH:22])(=[O:20])=[O:21])[C:9](=[O:11])[CH:10]=1)=[O:5]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 53910740HCID 53910740, compound

Product 1

HCID 54522853HCID 54522853, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

14.5 g of Intermediate A and 15.3 g of ethanolamine were mixed and made to react with each other over a period of 2 hours under a pressure reduced to 30 mm Hg inside the reaction container and a temperature kept at 120° C. outside the reaction container. After cooling to room temperature, the reaction product was dissolved in 30 ml of ethanol, and separated out in a crystallized condition upon addition of 300 ml of isopropanol. After filtration, the crystals were washed with isopropanol, and dried. Thus, 13 g (yield: 86.5%) of Intermediate C was obtained. Melting Point: 215°-219° C. (decomposed).

Workup

  1. customto react with each other over a period of 2 hours under a pressure
  2. customkept at 120° C. outside the reaction container
  3. customseparated out in a crystallized condition upon addition of 300 ml of isopropanol
  4. filtrationAfter filtration
  5. washthe crystals were washed with isopropanol
  6. customdried

Sources & evidence

ORD record
ord-80c2e40989604f328b40bc3b04205e32
Source dataset
uspto-grants-1989_05
Patent number
US04833246

Reaction notes

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