HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1762692Generated: November 4, 2026
Benzaldehyde → 3-Carboxy-1-(4-Sulfobenzyl)pyrazoline-5-one
https://huagongshe.com/reaction/1762692
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylic acid | HCID 9167391 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | ethyl 5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate | HCID 4056539 | — |
| Product | 3-Carboxy-1-(4-Sulfobenzyl)pyrazoline-5-one | HCID 54427297 | 82% |
Reaction Steps
3-Ethoxycarbonyl-1-phenylpyrazoline-5-one (F-1) was prepared in the same manner as in Synthesis 1-(1), except benzaldehyde was used in place of sodium 2-formylbenzenesulfonate. Further, (F-1) was hydrolyzed by the same method as used in Synthesis 1-(5) to be converted to 3-carboxy-1-phenylpyrazoline-5-one (F-2). 7 g of (F-2) was added to 28 ml of concentrated sulfuric acid and heated at 110° C. for 2 hours. After cooling, 140 ml of ethyl acetate was added to the reaction mixture and allowed to stand overnight to yield 7.8 g (yield: 82%) of Intermediate F. Melting Point: 276° C. (decomposed).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04833246 |
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| Source dataset | uspto-grants-1989_05 |
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| ORD ID | ord-64cd46c5b41a456e8658c1f3d494b2f5 |
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| Source note | uspto-grants-1989_05 |
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