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5,7-dihydro-6H-dibenz[c,e]azepine-6carbonitrile → 2-butyl 5,7-dihydro-6H-dibenz[c,e]azepine-6-thiocarboximidate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5,7-dihydro-6H-dibenz[c,e]azepine-6carbonitrile | HCID 19833886 | — |
| 反応物 | Sodium 2-butanethiolate | HCID 23677270 | — |
| 溶媒 | 2-Butanethiol | HCID 10560 | — |
| 生成物 | 2-butyl 5,7-dihydro-6H-dibenz[c,e]azepine-6-thiocarboximidate | HCID 20041715 | — |
反応手順
starting from 5,7-dihydro-6H-dibenz[c,e]azepine-6-carbonitrile and sodium 2-butanethiolate in 2-butanethiol there is obtained 2-butyl 5,7-dihydro-6H-dibenz[c,e]azepine-6-thiocarboximidate which is purified by flash chromatography on silica gel using n-hexane/ethyl acetate (1:1) as the eluent, 1H-NMR(CDCl3): 1.05 (t, CH2CH3), 1.42 (d, CH--CH3), 1.46-1.93 (m, CH2CH3), 2.81-3.37 (m, 1H), 4.41 (s, 4H), 5.1 (broad s, NH), 7.37-7.70 (8H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04833245 |
| 出典データセット | uspto-grants-1989_05 |
| ORD ID | ord-cc76b8b2c064426e8336c7ee74fd2003 |
| 出典メモ | uspto-grants-1989_05 |