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1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-(2-Sulfamoylphenylmethylthio)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 反応物 | 2-(Chloromethyl)benzenesulfonamide | HCID 13364627 | — |
| 反応物 | HCID 178418793 | HCID 178418793 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-(2-Sulfamoylphenylmethylthio)pyrimidine | HCID 20041750 | 85.2% |
反応手順
With cooling, 7.9 g of 97% 1,8-diazabicyclo[5.4.0]undec-7-ene are added to a suspension of 5.7 g of 98% 2-mercaptopyrimidine in 50 ml of acetonitrile. To the yellowish solution so obtained are added 10.3 g of 2-chloromethylbenzenesulfonamide. The reaction solution is stirred for 70 hours at 20°-22° C. and then diluted with 1 liter of water. The precipitate is isolated by filtration and dried, affording 12.0 g (85% of theory) of 2-(2-sulfamoylphenylmethylthio)pyrimidine of m.p. 128°-130° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04833252 |
| 出典データセット | uspto-grants-1989_05 |
| ORD ID | ord-1df107cb6e4649a0acd47d8ab224200b |
| 出典メモ | uspto-grants-1989_05 |