HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (2-chloro-4,5-difluorobenzoyl)propanedioate → Ethyl 3-(2-chloro-4,5-difluorophenyl)-3-oxopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (2-chloro-4,5-difluorobenzoyl)propanedioate | HCID 14425827 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Ethyl 3-(2-chloro-4,5-difluorophenyl)-3-oxopropanoate | HCID 14423850 | 73% |
Reaction Steps
A solution of 25.5 g of (2-chloro-4,5-difluorobenzoyl)propanedioic acid, diethyl ester in 500 ml of p-dioxane and 2.74 ml of water was refluxed for 3 hours, then evaporated to dryness and distilled on a Kugelrohr, giving 14.6 g of the desired compound as a bright yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04833270 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-50ced1a5ace846fd9c89ffe944b9815b |
| Source note | uspto-grants-1989_05 |