HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → Ethyl 2-(2-chloro-4,5-difluorobenzoyl)-3-ethoxyacrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Ethyl 3-(2-chloro-4,5-difluorophenyl)-3-oxopropanoate | HCID 14423850 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | Ethyl 2-(2-chloro-4,5-difluorobenzoyl)-3-ethoxyacrylate | HCID 54163438 | 94.3% |
Reaction Steps
A solution of 14.5 g of 2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid, ethyl ester and 12.27 g of triethyl orthoformate in 13 ml of acetic anhydride was heated at 150° C. for 2 hours and then evaporated to dryness, giving 16.59 g of the desired product as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04833270 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-41ed53989b1949c6b0e5fad7bdbe41cf |
| Source note | uspto-grants-1989_05 |