HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → HCID 178471872, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Ethyl 2-(2-chloro-4,5-difluorobenzoyl)-3-ethoxyacrylate | HCID 54163438 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178471872 | HCID 178471872 | — |
Reaction Steps
A 3.9 ml portion of cyclopropylamine was added dropwise to a solution of 16.25 g of 2-chloro-α-(ethoxymethylene)-4,5-difluoro-β-oxobenzenepropanoic acid, ethyl ester in 45 ml of ethanol, producing an exotherm. The solution was stirred for 1 hour, evaporated to dryness and the residue crystallized from hexane, giving 14.6 g of the desired compound, mp 55°-58° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04833270 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-ec094658caf14dee999a6a15da69f9c7 |
| Source note | uspto-grants-1989_05 |