HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → N-formyl-(3,5-difluorobenzyl)glycine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | N-(3,5-difluorobenzyl)-glycine methyl ester | HCID 14479943 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | N-formyl-(3,5-difluorobenzyl)glycine methyl ester | HCID 14254152 | 99.3% |
Reaction Steps
A solution of N-(3,5-difluorobenzyl)-glycine methyl ester (7.61 g, 0.0352 mole) and formic acid (1.33 ml, 0.0352 mole) was heated at reflux in xylene (60 ml) with azeotroic removal of water for 2.5 hours and the solvent was removed under vacuum to give the product as an oil (8.50 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04835154 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-68cedded969b42f18ae3112b229b2e43 |
| Source note | uspto-grants-1989_05 |