4-[1-(4-Nitropyrid-2-yl)piperidin-4-yl]benzenesulphonamide → 4-[1-(4-Aminopyrid-2-yl)piperidin-4-yl]benzenesulphonamide

Participants

Reaction Steps

A mixture of the product from part (i) (100 mg) and 5% palladium/carbon (25 mg) in ethanol (25 ml) and acetic acid (25 ml) was hydrogenated at 3.5 bars at room temperature for 3 hours. The catalyst was filtered off, the filtrate was evaporated and the residue was chromatographed on silica gel. Elution with dichloromethane/ethanol (19:1) gave some impurity and further elution with dichloromethane/ethanol/concentrated aqueous ammonia (90:10:1) gave the pure product. The combined product-containing fractions were evaporated to give the title compound as a monohydrate, m.p. 290°-295° (with decomp).

Provenance & Evidence