Sodium Chloride → HCID 14500552, compound

Participants

Reaction Steps

Ten grams of 4-cyano-N-(2,6-dimethylphenyl)benzamide and 3 grams of finely powdered potassium hydroxide were slurried in t-butanol and heated at reflux for 50 minutes. The homogeneous mixture was poured into a saturated sodium chloride solution and extracted in chloroform. Material which was insoluable in both the organic and water phases were recovered by filtration, crystallized from methanol, and provided the title compound in 43% yield, m.p. 246°-248° C.

Provenance & Evidence