Sodium Cyanide → HCID 14500538, compound

HRID 1762877Notes

Reaction equation

HRID 1762877 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1.[C-:17]#[N:18].[Na+]>CS(C)=O>[OH:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:17]#[N:18])=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 14500537HCID 14500537, compound

Product 1

HCID 14500538HCID 14500538, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

8-[(4-Hydroxyphenyl)amino]octanenitrile was prepared in 80% yield from 33.2 g [0.11 mol] of 4-[(7-bromoheptyl)amino]phenol and 26.5 g (0.52 mol) of sodium cyanide by the first procedure of Example 2, part d, except that DMSO was used in place of DMF as the solvent.

Sources & evidence

ORD record
ord-b44418e135bf428682c735d533d515dc
Source dataset
uspto-grants-1989_05
Patent number
US04835180

Reaction notes

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