Sodium Cyanide → HCID 14500540, compound

HRID 1762878Notes

Reaction equation

HRID 1762878 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1.[C-:18]#[N:19].[Na+]>>[OH:17][C:14]1[CH:15]=[CH:16][C:11]([NH:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:18]#[N:19])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 8929Sodium CyanideHCID 20039928HCID 20039928, compound

Product 1

HCID 14500540HCID 14500540, compoundYield 73%

Procedure

9-[(4-Hydroxyphenyl)amino]nonanenitrile was prepared in 73% yield from 37.5 g (0.11 mol) of 4-[(8-bromooctyl)amino]phenol and 27 g (0.55 mol) of sodium cyanide according to the procedure of Example 4, part c, except that the crude free base was precipitated from ethyl acetate solution with hexane.

Workup

  1. customexcept that the crude free base was precipitated from ethyl acetate solution with hexane

Sources & evidence

ORD record
ord-329d4b3adcce44c8ae9f009be13d9a4f
Source dataset
uspto-grants-1989_05
Patent number
US04835180

Reaction notes

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