HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaniline → 5-Aminosalicylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | 6-Bromohexanoyl chloride | HCID 89848 | — |
| Reactant | Methyl 5-amino-2-hydroxybenzoate | HCID 135127 | — |
| Product | 5-Aminosalicylic Acid | HCID 4075 | — |
| Product | HCID 14500512 | HCID 14500512 | — |
Reaction Steps
was prepared in quantitative yield from 40.0 g (0.24 mol) of methyl-5-aminosalicylate, 32.0 g (0.26 mol) of N,N-dimethylaniline and 46.5 g (0.22 mol) of 6-bromohexanoyl chloride according to the procedure of Example 9, part a. The methyl 5-aminosalicylate was obtained by Fischer esterification of 5-aminosalicylic acid. The product was not recrystallized, but was obtained directly from trituration in 1N HCl, mp 100°-102° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04835180 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-f0265e364c0c4b719109b8ad763fa598 |
| Source note | uspto-grants-1989_05 |