Water → HCID 54135067, compound

HRID 1762905Notes

Reaction equation

HRID 1762905 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([P:20]([C:27]2[CH:32]=[C:31]([C:33]([CH3:36])([CH3:35])[CH3:34])[C:30]([O:37][Si](C)(C)C)=[C:29]([C:42]([CH3:45])([CH3:44])[CH3:43])[CH:28]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:8]=[C:9]([C:16]([CH3:19])([CH3:18])[CH3:17])[C:10]=1[O:11][Si](C)(C)C)([CH3:4])([CH3:3])[CH3:2].O>CO>[C:16]([C:9]1[CH:8]=[C:7]([P:20]([C:27]2[CH:32]=[C:31]([C:33]([CH3:36])([CH3:35])[CH3:34])[C:30]([OH:37])=[C:29]([C:42]([CH3:45])([CH3:44])[CH3:43])[CH:28]=2)[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:10]=1[OH:11])([CH3:17])([CH3:18])[CH3:19]

Participants

4

Reactant 2

HCID 962WaterHCID 20039980HCID 20039980, compound

Product 1

HCID 54135067HCID 54135067, compoundYield 38.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1.0 g (1.5 mmol) of bis(3,5-di-tert-butyl-4-trimethylsilyloxyphenyl)phenylphosphine and 2.0 g of water in 25 ml of methanol is heated at reflux temperature for 4 hours. The solvent is removed in vacuo and the residue purified by flash chromatography (silica gel, 9:1 heptane:ethyl/acetate eluent) to give 0.3 g (34%) of a white solid, m.p. 138°-140° C.

Workup

  1. temperatureat reflux temperature for 4 hours
  2. customThe solvent is removed in vacuo
  3. customthe residue purified by flash chromatography (silica gel, 9:1 heptane:ethyl/acetate eluent)

Sources & evidence

ORD record
ord-f3eed2b34c2242ff9c82f8cf968420f0
Source dataset
uspto-grants-1989_05
Patent number
US04835202

Reaction notes

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