Hydrochloric Acid → HCID 20039785, compound

Participants

Reaction Steps

A solution of α-phenoxymethyl-2-pyridinemethanol hydrochloride (20.22 g, 0.08 mole) in 425 ml of methanol was hydrogenated for 2.5 hr in the presence of 1 g of platinum oxide at room temperature. TLC analysis (in 5% methanol-methylene chloride) showed that all the pyridine compound had been converted to the piperidine derivatives. Removal of methanol furnished an oil. The oil was dissolved in methylene chloride-hexane mixture and treated with ethereal hydrogen chloride. The resulting salt was triturated with acetone and recrystallized from methylenechloride-hexane-diethyl ether to give 5.28 g (25.5% of a white crystalline solid, m.p. 165°-171° C.

Provenance & Evidence