HCID 14500437, compound → HCID 14500417, compound

Participants

Reaction Steps

A solution of α-[(2,6-dimethylphenoxy)methyl]pyridine-2-methanol hydrochloride (11.20 g, 0.04 mole) in 200 ml of methanol was hydrogenated at room temperature with 1.4 g of platinum oxide for 45 minutes. The solution was filtered and the methanol removed by rotary evaporator. Trituration with ethyl ether gave a white solid which was recrystallized from methanol-ethyl ether (and dried at 100° C. overnight) to give 7.81 g (67.5%) of white crystalline product, m.p. 178°-179° C. with decomposition.

Provenance & Evidence