HCID 70381469, compound → HCID 13105642, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.6 g of 7-hydroxy-4-isopropylaminoacetylindole-2-carboxylic acid methyl ester hydrochloride in 80 ml of methanol is combined with 300 mg of 10% palladium-animal charcoal and shaken for 21/4 hours under normal pressure with hydrogen. The reaction mixture is then filtered and the filtrate evaporated to dryness under vacuum. The residue is triturated with acetonitrile, cooled to 0° C., and filtered, thus obtaining 1.41 g of 4-(1-hydroxy-2-isopropylaminoethyl)-7-hydroxyindole-2-carboxylic acid methyl ester, decomposition point 137°-139° C.

Provenance & Evidence