Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1762935Generated: October 31, 2026

5-Methoxyindole-2-carboxylic acid → 2-Methylpropyl 7-methoxy-1H-indole-2-carboxylate

https://huagongshe.com/reaction/1762935

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Methoxyindole-2-carboxylic acidHCID 168187—
SolventIsobutanolHCID 6560—
Product2-Methylpropyl 7-methoxy-1H-indole-2-carboxylateHCID 13089717119.8%

Reaction Steps

Under the conditions of Example 8(A), 8 g of 7-methoxyindole-2-carboxylic acid is converted into the acid chloride and the latter is reacted with isobutanol. After working up of the reaction product and recrystallization from petroleum ether, 6.2 g of 7-methoxyindole-2-carboxylic acid isobutyl ester is obtained, mp 100°-101° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04835175
Source datasetuspto-grants-1989_05
ORD IDord-fca02b4cf1fa4da4b94b8c41a0b42ce9
Source noteuspto-grants-1989_05