Methanol → HCID 70381997, compound

Participants

Reaction Steps

209 mg of 4-[2-(4-benzyloxyphenyl)-1-methylethyl-aminoacetyl]-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride is hydrogenated in 20 ml of methanol for 2.5 hours at room temperature and under normal pressure in the presence of 42 mg of 10% palladium-carbon. The mixture is filtered, the filtrate is concentrated under vacuum, and the residue is recrystallized from acetone/diethyl ether, thus obtaining 115 mg of 4-{1-hydroxy-2-[2-(4-hydroxyphenyl)-1-methylethylamino]ethyl}-7-hydroxy-indole-2-carboxylic acid ethyl ester hydrochloride, decomposition point 110° C.

Provenance & Evidence