Diethyl Ether → HCID 13243481, compound

Participants

Reaction Steps

4 g of 7-benzyloxy-4-(N-benzyl-N-tert-butylaminoacetyl)-2-indolecarboxylic acid ethyl ester is combined with 75 ml of absolute tetrahydrofuran and 150 ml of diethyl ether and stirred under ice cooling for 9 hours with 1.2 g of lithium aluminum hydride. Then a small amount of water is added to the reaction mixture, the precipitate is vacuum-filtered, washed with ethyl acetate/diethyl ether, the combined filtrates are concentrated, and the residue is recrystallized from diisopropyl ether, thus obtaining 3.4 g of 2-(N-benzyl-N-tert-butylamino) -1-(7-benzyloxy-2-hydroxymethylindol-4-yl)ethanol, mp 135.5°-136.5° C.

Provenance & Evidence