Ethyl 7-(benzyloxy)-4-formyl-1H-indole-2-carboxylate → 7-(Benzyloxy)-4-formyl-1H-indole-2-carboxylic acid

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Reaction Steps

2.26 g of 7-benzyloxy-4-formylindole-2-carboxylic acid ethyl ester is heated in a mixture of 15 ml of 1N sodium hydroxide solution and 15 ml of ethanol for one hour to 100° C. The ethanol is then distilled off under vacuum, the mixture is acidified with 10% hydrochloric acid and the precipitate is vacuum-filtered. The product is recrystallized from glacial acetic acid, thus obtaining 2.22 g of 7-benzyloxy-4-formylindole-2-carboxylic acid, mp 207° C.

Provenance & Evidence