Benzene, 1-(chloromethyl)-2-fluoro- → HCID 13756053, compound

Participants

Reaction Steps

In a mixture consisting of 150ml of dichloromethane and 100ml of 50% NaOH were comined 5.00 g of 9-amino-3,4-dihydro-acridin-1(2H)-one, 3ml (1 eq) of 2-fluorobenzylchloride and 1.20 g (0.15 eq) of tetrabutylammonium hydrogen sulfate. The bisphasic mixture was mechanically stirred overnight and 3ml of 2-fluorobenzylchloride was again added. After 4 hours of further stirring, the reaction was complete based on thin layer chromatography. The reaction mixture was partitioned between water and dichloromethane and the dichloromethane layer was separated, dried over MgSO4, filtered and evaporated to a solid.

Provenance & Evidence