Potassium Carbonate → HCID 54500913, compound

Participants

Reaction Conditions

Reaction Steps

6,7-Dichloro-2-(3-chloro-2-butenyl)-2,3-dihydro-5-hydroxy-2-propyl-1H-inden-1-one (24.5 g, 0.0716 mole) was stirred for 11/4 hours at 25° C. in a mixture of potassium carbonate (29.7 g, 0.215 mole) in dimethylformamide (85 ml). The suspension was cooled to 10° C. and trifluoromethanesulfonyl chloride (14.6 g, 0.087 mole) was added. The mixture was stirred 1/3 hour at 10° C., 11/2 hours at 25° C. and then poured over ice and extracted with diethyl ether. The organic extracts were washed with water, dried over MgSO4 and concentrated under vacuum to obtain 33.7 g of the product as an oil.

Provenance & Evidence