Acetic Anhydride → HCID 20309436, compound

HRID 1763234Notes

Reaction equation

HRID 1763234 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>N1C=CC=CC=1>[C:15]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=1)(=[O:17])[CH3:16]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 30173466-(2-Hydroxyphenyl)-3(2H)-pyridazinone

Product 1

HCID 20309436HCID 20309436, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineCatalyst

Procedure

A mixture of 6-(2-hydroxyphenyl)-3(2H)-pyridazinone (20 g), acetic anhydride (60 ml) and pyridine (10 drops) was heated and stirred on a steam-bath for 13/4 hours. The mixture was evaporated under reduced pressure, and the residual oil was treated with water (100 ml) and methanol (10 ml) and was allowed to crystallise to give 6-(2-acetoxyphenyl)-3(2H)-pyridazinone (22.7 g) m.p. 181°-183.5°. A sample recrystallised from 50% aqueous ethanol had m.p. 182.5°-184.5°.

Workup

  1. temperaturewas heated
  2. customThe mixture was evaporated under reduced pressure
  3. additionthe residual oil was treated with water (100 ml) and methanol (10 ml)
  4. customto crystallise

Sources & evidence

ORD record
ord-f8c1a66e89a547c4b2ec2ab8a9dfa4bc
Source dataset
uspto-grants-1978_09
Patent number
US04111935

Reaction notes

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