反应详情

A mixture of 6 g (0.02 mol) of 7-chloro-3,5-dihydro-2-methylamino-5-phenyl-4H-1,5-benzodiazepin-4-one, 25 ml of glacial acetic acid and 1.75 g (0.025 mol) of sodium nitrite was stirred stirred at 10°-20° for 1 hr. The reaction mixture was diluted with ice and water and stirred for another 15 min. The precipitated material was collected and dissolved in methylene chloride. The solution was washed with sodium bicarbonate solution, dried over sodium sulfate and evaporated. Crystallization from methylene chloride/hexane yielded the above-named product as yellow crystals, with mp 120°-125°. For analysis it was recrystallized like form methylene chloride/hexane, mp. 122°-125°.

1. stirringstirred at 10°-20° for 1 hr
2. stirringstirred for another 15 min
3. customThe precipitated material was collected
4. dissolutiondissolved in methylene chloride
5. washThe solution was washed with sodium bicarbonate solution
6. dry with materialdried over sodium sulfate
7. customevaporated
8. customCrystallization from methylene chloride/hexane